Protein Details: Glutamate receptor ionotropic; kainate 5

Protein ID

ICDB_Pro_1051

Protein Name

Glutamate receptor ionotropic; kainate 5

Gene Name

Grik5

Organism

Rattus norvegicus (Rat)

Length

979 amino acids

AlphaFoldDB

AF-Q63273-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1; GRIK2 and GRIK3 subunits.

Sequence

MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTGPRELTEHE

PDB Structures

3OM0 3OM1 3QLU 3QLV 7KS0 7KS3

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

High expression in the cerebral cortex; pyriform cortex; caudate-putamen; hippocampal complex; medial habenulata and granule cell layer of the cerebellum. Weak expression in globus pallidus; thalamus; colliculi and the reticular thalamic nucleus. Expressed at high levels in the trigeminal ganglion neurons. Expressed at high levels in the trigeminal ganglion neurons. Expressed at high levels in the trigeminal ganglion neurons.

DOI ID

10.1016/0896-6273(92)90098-x; 10.1523/jneurosci.17-17-06611.1997; 10.1016/s0896-6273(00)80404-3; 10.1523/jneurosci.23-22-08013.2003; 10.1016/j.celrep.2012.01.003; 10.1016/j.neuroscience.2014.08.009; 10.1016/j.jmb.2010.10.006; 10.1016/j.neuron.2011.05.038

RefSeq

NP_113696.1